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On of cytosine using S-adenosyl methionine and DNA as substrates. DNA methylation is a stable epigenetic mark that when located proximal to regulatory elements associated with transcription start sites, including promoters, most often facilitates the formation of a repressed chromatin state (reviewed in [33,34]). Approximately 70 of CpGs genome-wide are symmetrically methylated [35] . Regions of

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