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R complexes [41,42] . Genome-wide mapping of the localization of DNMT proteins to DNA in human differentiated and undifferentiated cells show that each DNMT binds to discrete and overlapping intragenic regions depending on cellular differentiation status [41] . Interestingly, comparisons between the genome-wide locations of DNA methylation and DNMT binding suggest that DNMTs exert methylation-inde

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