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Second group used methyl-CpGbinding domain (MBD) affinity purification followed by deep-sequencing [45] . In both cases, only a fraction of the total sites in the genome that can be methylated are assayed. Moreover, both approaches do not provide adequate coverage of mCpH sites in the genome. DNA methylation readers Proteins that read methylated (5mC) and hydroxymethylated (5hmC) DNA bind these mo

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